Publications

Aptamer Inhibitor of Von Willebrand Factor Induces Thrombolysis and Improves Vascular Patency Upon Immediate and Delayed Treatment of Stroke in an in vitro Microfluidic Model

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isth 2022

Effect of Novel Thrombolytic Aptamer BB-031 on Microfluidic Thrombolysis and VWF Function Dose-Response

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MDPI

Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

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AHA Journals

Abstract 45: Vwf Inhibitor Lyses Middle Cerebral Artery Occlusion After 6 Hours Of Large Vessel Occlusion Stroke

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AHA Journals

Abstract 187: Reversible Aptamer Inhibition of Von Willebrand Factor is a Potent Thrombolytic and Ameliorates Stroke Burden Following Vascular Injury Compared to Recombinant Tissue Plasminogen Activator

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AHA Journals

Abstract WP99: Reversible VWF Inhibitor Reduces Stroke Volumes Compared to TPA in Canine Model of Large Vessel Occlusion Stroke

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ScienceDirect

Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels

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AHA Journals

Abstract 522: VWF Inhibition by an RNA Aptamer Improves Functional Outcome Compared to rTPA in Ferric Chloride-induced Carotid Artery Thrombosis in Mice

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AHA Journals

Abstract 16728: Translating Thrombolytic Efficacy of Von Willebrand Factor Aptamer Inhibition From a Small to Large Animal Model of Carotid Occlusion

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AHA Journals

Abstract WP70: Aptamer Inhibition of Von Willebrand Factor Ameliorates Ischemic Stroke Burden in a Murine Model of Thromboembolic Stroke

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