Our Solution

Acute thrombolytic with reversal agent

Basking is developing the first reversible thrombolytic therapy for acute ischemic stroke (AIS). The technology is based on two decades of translational research on RNA aptamers as therapeutic agents for cardiovascular diseases conducted by company founders Bruce Sullenger and Dr. Shahid Nimjee at Duke University and The Ohio State University Wexner Medical Center.

The Company’s candidate drug, DTRI-031, is an RNA aptamer that inhibits von Willebrand Factor (vWF). Basking is co-developing a matched oligonucleotide reversal agent, DTRI-025, for as-needed, rapid reversal of DTRI-031. Basking’s paired therapy has the potential to extend the treatment window, significantly expand the population of patients that receive acute thrombolytic therapy and aligns perfectly with the urgent need in medicine for precision-based therapeutics in cardiovascular disease.

Science

DTRI-031

DTRI-031 is an RNA aptamer that potently and rapidly inhibits the A1 domain of von Willebrand Factor (VWF). Targeting VWF, a key mediator of platelet rich clot formation and stability, represents a novel approach to improve the overall efficacy of pharmacological revascularization. DTRI-031 has demonstrated successful recanalization of occluded arteries in multiple animal models including a canine model of cerebrovascular stroke.

DTRI-031 Improved Stroke Outcomes vs. Control

67% reduction in stroke volume by MRI


DTRI-025

DTRI-025 is a rationally designed reversal agent that neutralizes DTRI-031 activity and normalizes hemostasis within minutes of administration in the event of bleeding. Immediate restoration of normal hemostasis will enable surgeons to intervene and address the bleed, thereby limiting associated downstream morbidity and mortality.

Reversal by DTRI-025 in Canines

Development Program Status

DTRI-031 will enter clinical development in Q2 2021. DTRI-025 is beginning IND enabling development in Q4 2020.

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